CBR1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0121-50, MB0121-100

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P16152

Host: Mouse

Reactivity: Human

Applications: WB, ICC

All Applications: WB:1:1000
ICC:1:100

Background: Carbonyl reductase is one of several monomeric,NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds.This enzyme is widely distributed in human tissues. Another carbonyl reductase gene,CRB3,lies close to this gene on chromosome 21q. NADPH-dependent reductase with broad substrate specificity.Catalyzes the reduction of a wide variety of carbonyl compounds including quinones,prostaglandins, menadione,plus various xenobiotics.Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha.Can bind glutathione,which explains its higher affinity for glutathione-conjugated substrates.Catalyzes the reduction of S-nitrosoglutathione.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CBR1 mAb detects endogenous levels of CBR1 protein.

Bioworld Molecular Weight: Predicted band size: 30KDa
Observed band size: 30KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot detection of CBR1 in Hela, A431 and MDA-MB-468 cell lysates using CBR1 antibody (1:1000 diluted)., Immunocytochemistry stain of Hela using CBR1 antibody (1:100).

Alternative Name: 15 hydroxyprostaglandin dehydrogenase [NADP+]; 15-hydroxyprostaglandin dehydrogenase [NADP+]; Carbonyl reductase [NADPH] 1; Carbonyl Reductase 1; CBR 1; CBR1; CBR1; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; Prostaglandin 9-ketoreductase; Prostaglandin E(2) 9 reductase; Prostaglandin-E(2) 9-reductase; SDR21C1; CBR; hCBR1; SDR21C1

Immunogen: Recombinant full length Human CBR1.

Conjugate: Unconjugated

Modification: Unmodified