Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC50 of 4.2 nM for HeLa cells.

Product information

CAS Number: 1349904-82-0

Molecular Weight: 676.70

Formula: C34H44O14

Chemical Name: (1S,2S,3R,5S,7S,9S,10R,11R,12S,13S,14R,15R,16S,17S,18S,20S,23S,24S,25R,26R)-13,14-bis(acetyloxy)-3,23,26-trihydroxy-11,15,17,23,24-pentamethyl-4,22-dioxo-8,19,21-trioxaoctacyclo[13.11.0.0²,¹².0⁵,¹¹.0⁷,⁹.0¹⁶,²⁵.0¹⁸,²⁰.0²⁰,²⁴]hexacosan-10-yl acetate

Smiles: C[C@H]1[C@H]2[C@@H]([C@H](O)[C@H]3[C@H]4[C@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]32C)[C@]2(C)[C@H](C[C@@H]3O[C@@H]3[C@@H]2OC(C)=O)C(=O)[C@@H]4O)[C@]2(C)[C@]3(O[C@H]31)OC(=O)[C@@]2(C)O

InChiKey: BWKYBGRKQMTOQL-MPOFNYKTSA-N

InChi: InChI=1S/C34H44O14/c1-10-17-20(32(7)33(8,42)29(41)48-34(32)26(10)47-34)23(40)18-16-19(25(43-11(2)35)28(31(17,18)6)45-13(4)37)30(5)14(21(38)22(16)39)9-15-24(46-15)27(30)44-12(3)36/h10,14-20,22-28,39-40,42H,9H2,1-8H3/t10-,14+,15-,16-,17-,18+,19+,20-,22+,23+,24-,25-,26-,27-,28-,30-,31+,32-,33+,34+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 110 mg/mL (162.55 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.