Recombinant Human BCL-W/BCL2L2 Protein (His Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSH032116-10, PKSH032116-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: BCL-W; BCL2L2

Target Synonym: Bcl-2-Like Protein 2; Bcl2-L-2; Apoptosis Regulator Bcl-W; BCL2L2; BCLW; KIAA0271

UNIProt ID: Q92843

Research Areas: Cell biology; Cancer

Target Species: Human

Expression Host: E.coli

Fusion Tag: C-6His

Accession: Q92843

Background: Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Sequence: Ala2-Thr172

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 19.9 kDa

Observed MW: 18 kDa

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Research Use Only