AMG-176 is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM.

Product information

CAS Number: 1883727-34-1

Molecular Weight: 613.21

Formula: C33H41ClN2O5S

Chemical Name: (1S,3'R,6'R,7'S,11'S,12'R)-6-chloro-7'-methoxy-11',12'-dimethyl-3,4-dihydro-2H-20'-oxa-13'λ⁶-thia-1',14'-diazaspiro[naphthalene-1,22'-tetracyclo[14.7.2.0³,⁶.0¹⁹,²⁴]pentacosane]-8',16',18',24'-tetraene-13',13',15'-trione

Smiles: CO[C@H]1C=CC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC=C3OC[C@@]4(CN(C[C@@H]5CC[C@H]51)C3=C2)CCCC1=CC(Cl)=CC=C41 |t:3|

InChiKey: JQNINBDKGLWYMU-KYVUIAPPSA-N

InChi: InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38,39)22(21)2/h4,8,10-11,13-14,16-17,21-22,25,27,30H,5-7,9,12,15,18-20H2,1-3H3,(H,35,37)/b8-4-/t21-,22+,25-,27+,30-,33-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (101.92 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells.

Products are for research use only. Not for human use.