cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

Product information

CAS Number: 1819366-84-1

Molecular Weight: 563.53

Formula: C26H31F6N3O4

Synonym:

cis22a

cis 22a

Chemical Name: 1-(pyridin-3-yl)-4-((1s,4s)-4-(m-tolyl)cyclohexyl)piperazine bis(2,2,2-trifluoroacetate)

Smiles: CC1=CC(=CC=C1)[C@@H]1CC[C@@H](CC1)N1CCN(CC1)C1=CN=CC=C1.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F

InChiKey: UMKPISXYUQWXJJ-XWOHEVPJSA-N

InChi: InChI=1S/C22H29N3.2C2HF3O2/c1-18-4-2-5-20(16-18)19-7-9-21(10-8-19)24-12-14-25(15-13-24)22-6-3-11-23-17-22;2*3-2(4,5)1(6)7/h2-6,11,16-17,19,21H,7-10,12-15H2,1H3;2*(H,6,7)/t19-,21+;;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

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