YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity.

Product information

CAS Number: 708991-09-7

Molecular Weight: 292.36

Formula: C13H16N4O2S

Chemical Name: 4-({[3-methoxy-2-(prop-2-en-1-yloxy)phenyl]methyl}amino)-4,5-dihydro-1H-1,2,4-triazole-5-thione

Smiles: COC1=CC=CC(CNN2C=NNC2=S)=C1OCC=C

InChiKey: NHJCZZWENDYDEP-UHFFFAOYSA-N

InChi: InChI=1S/C13H16N4O2S/c1-3-7-19-12-10(5-4-6-11(12)18-2)8-15-17-9-14-16-13(17)20/h3-6,9,15H,1,7-8H2,2H3,(H,16,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.