TRAF6 Rabbit Monoclonal Antibody

Catalogue Numbers: MB66396-50, MB66396-100

Sizes: 50µl, 100µl

Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Swiss-Prot: Q9Y4K3

Host: Rabbit

Reactivity: Human, Rat

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2 .
Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.
Leads to the activation of NF-kappa-B and JUN.
Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity).
Represses c-Myb-mediated transactivation, in B-lymphocytes.
Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor .
Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity).
Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity).
Participates also in the TCR signaling by ubiquitinating LAT.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of TRAF6 protein.

Extra Notes: Western blot analysis of TRAF6 expression in K562 (A), rat brain (B), C6 (C), Hela (D) whole cell lysates.

Bioworld Molecular Weight: ~ 59 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: RNF85; TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85

Immunogen: A synthetic peptide of human TRAF6

Conjugate: Unconjugated

Modification: Unmodified