QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.

Product information

CAS Number: 24003-58-5

Molecular Weight: 343.30

Formula: C16H27BrN2O

Chemical Name: {[(2,6-dimethylphenyl)carbamoyl]methyl}triethylazanium bromide

Smiles: [Br-].CC1C=CC=C(C)C=1NC(=O)C[N+](CC)(CC)CC

InChiKey: DLHMKHREUTXMCH-UHFFFAOYSA-N

InChi: InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro . QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner. QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death . QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 10% of control amplitude . QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- .

In Vivo:

QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.

Products are for research use only. Not for human use.