PCI-33380 is an irreversible and selective Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).

Product information

CAS Number: 1022899-36-0

Molecular Weight: 855.78

Formula: C46H52BF2N11O3

Chemical Name: 4-{2-[(2-{4-[(2E)-4-{3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethyl)carbamoyl]ethyl}-2,2-difluoro-10,12-dimethyl-1λ⁵,3-diaza-2-boratricyclo[7.3.0.0³,⁷]dodeca-1(12),4,6,8,10-pentaen-1-ylium-2-uide

Smiles: CC1C=C(C)C2=CC3=CC=C(CCC(=O)NCCN4CCN(C/C=C/C(=O)N5CC(CCC5)N5N=C(C6=C(N)N=CN=C56)C5C=CC(=CC=5)OC5C=CC=CC=5)CC4)N3[B-](F)(F)[N+]=12

InChiKey: YUGFMNZIROEBNV-YRNVUSSQSA-N

InChi: InChI=1S/C46H52BF2N11O3/c1-32-28-33(2)58-40(32)29-36-15-14-35(59(36)47(58,48)49)16-19-41(61)51-20-23-56-26-24-55(25-27-56)21-7-11-42(62)57-22-6-8-37(30-57)60-46-43(45(50)52-31-53-46)44(54-60)34-12-17-39(18-13-34)63-38-9-4-3-5-10-38/h3-5,7,9-15,17-18,28-29,31,37H,6,8,16,19-27,30H2,1-2H3,(H,51,61)(H2,50,52,53)/b11-7+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 50 mg/mL (58.43 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PCI-33380 bound to Btk could be detected by denaturing gel electrophoresis and fluorescent gel scanning.

Products are for research use only. Not for human use.