VEGFD Monoclonal Antibody

Catalogue Numbers: MB66725-50, MB66725-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: O43915

Host: Mouse

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis.Several growth factors with angiogenic activity have been described. These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). Several forms of VEGF have been identified, including VEGF, VEGF-B, VEGF-C and VEGF-D (also designated FIGF).Characteristic of VEGF proteins, the central region of VEGF-D contains eight cysteine residues.These residues are essential for homodimerization. VEGF-D may play a role in tumor progression, as it is induced by c-Fos, which is required for conversion of early stage tumors to malignant tumors. It has been observed that overexpression of VEGF-D induces morphological changes in fibroblasts.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of VEGFD protein.

Extra Notes: Western blot analysis of VEGFD expression in MCF7 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: VEGFD; Vascular endothelial growth factor D; VEGF-D; c-Fos-induced growth factor; FIGF

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human VEGFD. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified