PLS1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES10002-50, ES10002-100

Citations, Manuals and MSDS Available upon request.

Background: cofactor:Calcium., function:May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system., function:May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation., induction:By phosphorylation by PKC. Induced by INFB1 in response to a viral infection., online information:Scramblase entry, PTM:Known to be palmitoylated at one, yet undefined, site., similarity:Belongs to the phospholipid scramblase family., subunit:Interacts with ABL., tissue specificity:Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from human protein . at AA range: 170-250

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 34kD

Human Gene ID: 5359

Human SWISS Prot NO: O15162

Subcellular Location: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Localizes to the perinuclear region in the presence of RELT (PubMed:22052202). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925).

Research Use Only